Originally recorded July 13 as part of the ASAN 2021 Summer Webinar Series, see https://addictionnursing.org/summer for details. Presenter: William J. Lorman, RN, JD, PhD, MSN, PMHNP-BC, NCPsyA, FAAN; Insight Psychological Services; Willow Grove, Pennsylvania This presentation reviews the neurobiological theories regarding the onset and maintenance of the addictive process. We review descriptors related to addiction and its treatment. We also examine issues related to the intoxication and withdrawal syndromes for alcohol and opiates. Learner Objectives: Describe the final common pathway for reward and pleasure. Define the term Tolerance as it relates to drug addiction. Describe contemporary theories/models of drug addiction. Nursing CE: This presentation is not eligible for Nursing CE.