Mercy Mumba, PhD, RN, FAAN; Associate Professor and Founding Director, Center for Substance Use Research and Related Conditions; Capstone College of Nursing, The University of Alabama Odunayo Elijah, M.Sc; Graduate Research Assistant; Capstone College of Nursing, The University of Alabama Description The paper reviewed the relationship between substance use and sleep quality, providing insights into the impact of substance use on sleep and vice versa. We identified a bi-directional relationship between substance use and sleep, where substance use leads to disruptions in sleep, and poor sleep is a risk factor for both present and future substance use. Addressing sleep quality in substance use disorder interventions can be beneficial. Physical activity, treatments, psychosocial support, behavioral change, and educational tools can improve sleep quality. Learner Objectives Examine the impact of substance use on sleep quality and the role of sleep quality as a risk factor for substance use. Highlight the importance of incorporating strategies to improve sleep quality in substance use disorder interventions. Nursing CE This event is approved for Nursing CE with the California Board of Nursing.