Description With an eye for ensuring that persons with opioid use disorder (OUD) receive adequate and humane pain care, this presentation will focus on what is known about the pain responses and pain sensitivity of persons with OUD with implications for management of their pain. Putative evidence for opioid-induced hyperalgesia in this patient population will be reviewed, as will data suggesting that individual differences in pain sensitivity may predict the development of OUD. Regardless of underlying mechanisms, it is argued that complaints of pain from patients with OUD should be taken seriously and managed aggressively. Learner Objectives Describe the overlap between pain and addiction systems. Summarize what is known about the pain responses of persons with opioid use disorder. Explain how pain sensitivity may predict risk for opioid use disorder. Presenter Peggy Compton, RN, PhD, FAAN, FIAAN; Professor, van Ameringen Endowed Chair, Department of Family and Community Health, University of Pennsylvania School of Nursing Dr. Compton is a Professor and the van Ameringen Endowed Chair in the Department of Family and Community Health at the University of Pennsylvania School of Nursing. Her area of clinical expertise is the intersection of opioids, addiction and pain, and her novel data have contributed to a growing body of literature on the phenomenon of opioid-induced hyperalgesia, as well as informed guidelines for the management of pain in persons with opioid addiction or on maintenance opioid therapy. She has published extensively in the scientific literature on substance use disorder in chronic pain patients on opioid therapy, and the pain responses of opioid addicts with and without chronic pain. Nursing CE: This event is not eligible for Nursing CEs